Hydrogen Bond Variations of Influenza A Viruses During Adaptation in Human
Identifieur interne : 000301 ( Main/Exploration ); précédent : 000300; suivant : 000302Hydrogen Bond Variations of Influenza A Viruses During Adaptation in Human
Auteurs : Jiejian Luo [République populaire de Chine] ; Lizong Deng [République populaire de Chine] ; Xiao Ding [République populaire de Chine] ; Lijun Quan [République populaire de Chine] ; Aiping Wu [République populaire de Chine] ; Taijiao Jiang [République populaire de Chine]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
Many host specific mutations have been detected in influenza A viruses (IAVs). However, their effects on hydrogen bond (H-bond) variations have rarely been investigated. In this study, 60 host specific sites were identified in the internal proteins of avian and human IAVs, 27 of which contained mutations with effects on H-bonds. Besides, 30 group specific sites were detected in HA and NA. Twenty-six of 36 mutations existing at these group specific sites caused H-bond loss or formation in at least one subtype. The number of mutations in isolations of 2009 pandemic H1N1, human-infecting H5N1 and H7N9 varied. The combinations of mutations and H-bond changes in these three subtypes of IAVs were also different. In addition, the mutations in isolations of H5N1 distributed more scattered than those in 2009 pandemic H1N1 and H7N9. Eight wave specific mutations in isolations of the fifth H7N9 wave were also identified. Three of them, R140K in HA, Y170H in NA, and R340K in PB2, were capable of resulting in H-bond loss. As mentioned above, these host or group or wave specific H-bond variations provide us with a new field of vision for understanding the changes of structural features in the human adaptation of IAVs.
Url:
DOI: 10.1038/s41598-017-14533-3
PubMed: 29085020
PubMed Central: 5662722
Affiliations:
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Academy of Sciences,</institution></institution-wrap>Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1797 8419</institution-id><institution-id institution-id-type="GRID">grid.410726.6</institution-id><institution>University of the Chinese Academy of Sciences,</institution></institution-wrap>Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Deng, Lizong" sort="Deng, Lizong" uniqKey="Deng L" first="Lizong" last="Deng">Lizong Deng</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005 China</nlm:aff><country 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Union Medical College, Beijing, 100005 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0198 0694</institution-id><institution-id institution-id-type="GRID">grid.263761.7</institution-id><institution>Suzhou Institute of Systems Medicine,</institution></institution-wrap>Suzhou, Jiangsu 215123 China</nlm:aff><wicri:noCountry code="subfield">Jiangsu 215123 China</wicri:noCountry></affiliation></author><author><name sortKey="Quan, Lijun" sort="Quan, Lijun" uniqKey="Quan L" first="Lijun" last="Quan">Lijun Quan</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0198 0694</institution-id><institution-id institution-id-type="GRID">grid.263761.7</institution-id><institution>Suzhou Institute of Systems Medicine,</institution></institution-wrap>Suzhou, Jiangsu 215123 China</nlm:aff><wicri:noCountry code="subfield">Jiangsu 215123 China</wicri:noCountry></affiliation></author><author><name sortKey="Wu, Aiping" sort="Wu, Aiping" uniqKey="Wu A" first="Aiping" last="Wu">Aiping Wu</name><affiliation wicri:level="3"><nlm:aff 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first="Taijiao" last="Jiang">Taijiao Jiang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1792 5640</institution-id><institution-id institution-id-type="GRID">grid.418856.6</institution-id><institution>Key Laboratory of Protein & Peptide Pharmaceuticals, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences,</institution></institution-wrap>Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff3">Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0198 0694</institution-id><institution-id institution-id-type="GRID">grid.263761.7</institution-id><institution>Suzhou Institute of Systems Medicine,</institution></institution-wrap>Suzhou, Jiangsu 215123 China</nlm:aff><wicri:noCountry code="subfield">Jiangsu 215123 China</wicri:noCountry></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Many host specific mutations have been detected in influenza A viruses (IAVs). However, their effects on hydrogen bond (H-bond) variations have rarely been investigated. In this study, 60 host specific sites were identified in the internal proteins of avian and human IAVs, 27 of which contained mutations with effects on H-bonds. Besides, 30 group specific sites were detected in HA and NA. Twenty-six of 36 mutations existing at these group specific sites caused H-bond loss or formation in at least one subtype. The number of mutations in isolations of 2009 pandemic H1N1, human-infecting H5N1 and H7N9 varied. The combinations of mutations and H-bond changes in these three subtypes of IAVs were also different. In addition, the mutations in isolations of H5N1 distributed more scattered than those in 2009 pandemic H1N1 and H7N9. Eight wave specific mutations in isolations of the fifth H7N9 wave were also identified. Three of them, R140K in HA, Y170H in NA, and R340K in PB2, were capable of resulting in H-bond loss. As mentioned above, these host or group or wave specific H-bond variations provide us with a new field of vision for understanding the changes of structural features in the human adaptation of IAVs.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lozano, R" uniqKey="Lozano R">R Lozano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cauldwell, Av" uniqKey="Cauldwell A">AV Cauldwell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Jong, Md" uniqKey="De Jong M">MD De Jong</name></author><author><name sortKey="Hien, Tt" uniqKey="Hien T">TT Hien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T Watanabe</name></author><author><name sortKey="Watanabe, S" uniqKey="Watanabe S">S Watanabe</name></author><author><name sortKey="Maher, Ea" uniqKey="Maher E">EA Maher</name></author><author><name 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Buonagurio</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Treanor, Jj" uniqKey="Treanor J">JJ Treanor</name></author><author><name sortKey="Snyder, Mh" uniqKey="Snyder M">MH Snyder</name></author><author><name sortKey="London, Wt" uniqKey="London W">WT London</name></author><author><name sortKey="Murphy, Br" uniqKey="Murphy B">BR Murphy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Godzik, A" uniqKey="Godzik A">A Godzik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Lycett, Sj" uniqKey="Lycett S">SJ Lycett</name></author><author><name sortKey="Brown, Ajl" uniqKey="Brown A">AJL Brown</name></author><author><name sortKey="Leigh Brown, Aj" uniqKey="Leigh Brown A">AJ Leigh Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lycett, Sj" uniqKey="Lycett S">SJ Lycett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nobusawa, E" uniqKey="Nobusawa E">E Nobusawa</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Katoh, K" uniqKey="Katoh K">K Katoh</name></author><author><name sortKey="Standley, Dm" uniqKey="Standley D">DM Standley</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Berman, Hm" uniqKey="Berman H">HM Berman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Cao, Y" uniqKey="Cao Y">Y Cao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcdonald, Ik" uniqKey="Mcdonald I">IK McDonald</name></author><author><name sortKey="Thornton, Jm" uniqKey="Thornton J">JM Thornton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Magnan, Cn" uniqKey="Magnan C">CN Magnan</name></author><author><name sortKey="Baldi, P" uniqKey="Baldi P">P Baldi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bloom, Jd" uniqKey="Bloom J">JD Bloom</name></author><author><name sortKey="Drummond, Da" uniqKey="Drummond D">DA Drummond</name></author><author><name sortKey="Arnold, Fh" uniqKey="Arnold F">FH Arnold</name></author><author><name sortKey="Wilke, Co" uniqKey="Wilke C">CO Wilke</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Luo, Jiejian" sort="Luo, Jiejian" uniqKey="Luo J" first="Jiejian" last="Luo">Jiejian Luo</name></noRegion><name sortKey="Deng, Lizong" sort="Deng, Lizong" uniqKey="Deng L" first="Lizong" last="Deng">Lizong Deng</name><name sortKey="Ding, Xiao" sort="Ding, Xiao" uniqKey="Ding X" first="Xiao" last="Ding">Xiao Ding</name><name sortKey="Jiang, Taijiao" sort="Jiang, Taijiao" uniqKey="Jiang T" first="Taijiao" last="Jiang">Taijiao Jiang</name><name sortKey="Jiang, Taijiao" sort="Jiang, Taijiao" uniqKey="Jiang T" first="Taijiao" last="Jiang">Taijiao Jiang</name><name sortKey="Luo, Jiejian" sort="Luo, Jiejian" uniqKey="Luo J" first="Jiejian" last="Luo">Jiejian Luo</name><name sortKey="Quan, Lijun" sort="Quan, Lijun" uniqKey="Quan L" first="Lijun" last="Quan">Lijun Quan</name><name sortKey="Wu, Aiping" sort="Wu, Aiping" uniqKey="Wu A" first="Aiping" last="Wu">Aiping Wu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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